Activated iNKT cells promote memory CD8+ T cell differentiation during viral infection.

Activated iNKT cells promote memory CD8+ T cell differentiation during viral infection.

Blog Article

α-Galactosylceramide (α-GalCer) is the prototypical lipid ligand read more for invariant NKT cells.Recent studies have proposed that α-GalCer is an effective adjuvant in vaccination against a range of immune challenges, however its mechanism of action has not been completely elucidated.A variety of delivery methods have been examined including pulsing dendritic cells with α-GalCer to optimize the potential of α-GalCer.These methods are currently being used in a variety of clinical trials in patients with advanced cancer but cannot be used in the context of vaccine development against pathogens due to their complexity.Using a simple delivery method, we evaluated α-GalCer adjuvant properties, using the mouse model for cytomegalovirus (MCMV).

We measured lolasalinas.com several key parameters of the immune response to MCMV, including inflammation, effector, and central memory CD8(+) T cell responses.We found that α-GalCer injection at the time of the infection decreases viral titers, alters the kinetics of the inflammatory response, and promotes both increased frequencies and numbers of virus-specific memory CD8(+) T cells.Overall, our data suggest that iNKT cell activation by α-GalCer promotes the development of long-term protective immunity through increased fitness of central memory CD8(+) T cells, as a consequence of reduced inflammation.